The Hope Diamond Mystery is a 1921 American 15-chapter action film serial directed by Stuart Paton and featuring Grace Darmond, George Chesebro, May Yohe, and Boris Karloff.

[1] The screenplay was written by Charles Goddard and John B. Clymer, based on an autobiographical story by May Yohe (who co-stars as herself).

[1] The curse of the legendary blue Hope Diamond on all its owners is dramatized, beginning with the gem's discovery in 17th Century India.

This serial was shot on the Universal Pictures lot and a custom-built set, the "Temple of Sita," which reportedly cost $100,000 to build.

When watching the film, there are multi-colored tints in a single scene, reminiscent of the old hand-colored shorts of Georges Méliès.