The first service was held on January 20, 1857 at Constitution Hall, a building used by John Farnsworth for his general merchandise business.

The final fundraising push was initiated by Bishop Frank Rosebrook Millspaugh and Dean J. P. DeBevers Kaye.

Services were held in the Great Hall utilizing the old walnut altar, which had been saved, until the cathedral was reopened on October 1, 1978.

A renovation of the 1951 Cloister building was completed in late 2014, featuring a two story tall main entrance Common Room.

A capital campaign is currently underway to build a new main floor parish hall to the south onto the Bethany Place grounds of the Diocese of Kansas.

[3] A 1921 history book by Dean J.P. DeBevers Kaye states, the towers of French design (eventually surmounted by spires) resemble in some respects the Church of St. Corentin, at Quimper, in Brittany.

The interior features an oak wood truss ceiling that is supported by hammered beams and columns with hand carved stone capitals.