[1] A cardiologist from San Francisco in 1999, she assists the Eighth Doctor in defeating the renegade Time Lord, the Master.

He subsequently regenerates into his eighth incarnation, and involves Grace in his fight to prevent the Master from opening the Eye of Harmony and destroying the Earth at the stroke of midnight on New Year's Day, 2000.

She also rapidly develops a romantic attachment to the Doctor, stating at one point, "I finally meet the right guy and he's from another planet."

In Prisoners of Time, a series to celebrate the 50th anniversary, the Doctor meets her soon after the events of the TV Movie.

Originally, Grace Holloway was to appear in the second Eighth Doctor novel, Vampire Science, but legal issues with the BBC and Universal prevented this from happening.