Her first major appearance on the screen was in the 1986 King Ampaw/Peter Wohlgemuth-Reinery co-produced Afro Movies comic film "Juju," where she played the wife of fellow veteran actor Joe Eyison, alongside the likes of Emmanuel Agbenowu, Grace Ofoe, Osei Kwabena, and Evans Oma Hunter, among others.
Some of her most notable movies include Lost Hope, Dza Gbele, Matters of the Heart, Sekina, Expectations, Jewels, Beasts of No Nation (2015), Ties That Bind (2011), Sinking Sands (2011), Nana Akoto (1985), Escape to Love (1996), and The Other Side of The Rich (1992), among others.
Nonetheless, she still performs minor roles in movies and drama, which require less physical movement and also provide greater scope for onset improvisation.
Nortey has furthermore stressed the need for actors to obtain formal education and academic training in acting before pursuing a full-time career in the industry.
[citation needed] In her later years, Grace Nortey encountered the typical challenges associated with aging, such as health issues and a reduced role in the entertainment industry.