The 2016 presidential campaign of Grace Poe was announced at the Bahay ng Alumni at her alma mater, the University of the Philippines Diliman, Quezon City, on September 16, 2015.

[10] During Poe's trip in California with her mother, veteran actress Susan Roces, she was appointed by President Benigno Aquino III to serve at the Movie and Television Review and Classification Board (MTRCB) as a chairwoman last October 10, 2010.

Later on, due to her excellent work, President Aquino extended her term as a chairwoman of MTRCB, in which she continued serving until October 2, 2012, before she ran as a senator candidate.

And with God’s grace, I offer myself for the country’s highest calling as your President.Grace Poe's surprising first-place finish in the 2013 Senate election made her a likely contender for the presidency but she dismissed any plans of running in April 2014, saying she was not considering "anything higher at this point.

Poe said that "We discussed his intention to choose a candidate who, first and foremost, has the trust of the nation, and, secondly, has the potential to win in the election, in order to sustain the reforms especially against corruption and the pro-poor programs of the government."

Poe also observed that the attacks from UNA only began after she signed the Senate Blue Ribbon subcommittee report recommending plunder and graft cases against Binay.

[28] With the candidacy of Grace Poe for president, the Liberal Party surrendered on courting the senator to be the running mate of Mar Roxas.

[29] On September 16, 2015, Poe declared her presidential bid, in front of hundreds of supporters, family and friends at the Bahay ng Alumni, University of the Philippines, Diliman, Quezon City under the newly coalition of Partido Pilipinas, composed of Bagong Alyansang Makabayan and is led by the Nationalist People's Coalition.

Opposition party United Nationalist Alliance, on the other hand, questioned Poe's citizenship, claiming at the time of the elections, she is still short of the 10-year constitutional residency requirement for the presidential race.

[33][34][35] Sheryl Cruz, actress and adoptive cousin of Poe, withdrawn her support to the Senator's presidential campaign recently.

[36] On December 1, the COMELEC's second division had formally disqualified Poe from running as president in the 2016 elections and cancelled her filed Certificate of Candidacy for not failing to meet with citizenship and residency requirements.

The first division, voted 2–1 in favor of the petition filed by former Senator Francisco Tatad, DLSU professor Antonio Contreras and UE law dean Amado Valdez to disqualify and cancel the certificate of candidacy of Poe.

The campaign of both Poe and Escudero started with a proclamation rally held in the historical Plaza Miranda, Quiapo, Manila on February 9, 2016.

[2] On March 8, 2016, the Supreme Court decided to allow Poe to run for president and reverse the decision of the COMELEC to disqualify her in the 2016 presidential elections, voting 9–6.

[6] Former president and former Manila mayor Joseph Estrada has secured his endorsement to Poe as his presidential choice during his proclamation rally at the Liwasang Bonifacio on March 28, 2016.

[43] The Poe's campaign team also officially released a collection of special stickers for Viber messaging app on smartphones.

[44] Grace Poe introduced her running mate, fellow Senator Francis Escudero, in an event that was held at the Kalayaan Hall, Club Filipino, San Juan, weeks after Mar Roxas was endorsed by President Noynoy Aquino at the same place (July 31, 2015).

Poe is the main proponent of the Freedom of Information (FOI) Bill and the official face of the government transparency movement in the Philippines.

Being the daughter of a National Artist for Cinema, FPJ, she is a strong advocate for the enhancement and internationalization of Philippine culture and the arts, especially among the youth.

Poe wants to expand the coverage of PhilHealth, increase the basic pay of medical workers into 25,000 pesos, modernize all public hospitals, and to establish special barangay health centers nationwide.

Poe and Escudero revealed that 11 candidates were named on the initial list of the senatorial slate that will formed but details were not disclosed.

[55] In September 2015, Poe endorsed Bayan Muna representative Neri Colmenares as the first senatorial bet on her formed coalition for the 2016 elections.

[72] In October 2015, Poe-Escudero tandem finally announced in an event held in Club Filipino, San Juan, the complete senatorial slate for the "Partido Galing at Puso" coalition:[73]