Graffignana (Lodigiano: Grafignàn) is a comune (municipality) in the Province of Lodi in the Italian region Lombardy, located about 40 km (25 mi) southeast of Milan and about 13 km (8.1 mi) south of Lodi.

Graffignana borders the following municipalities: Sant'Angelo Lodigiano, Villanova del Sillaro, Borghetto Lodigiano, San Colombano al Lambro, Miradolo Terme.

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