Graham is a city in southwestern Nodaway County, Missouri, United States.

[5] A post office called Graham has been in operation since 1852, however was out of service from 2014 to 2020 due to the building being an extremely hazardous location.

[6] Simpson's College was listed on the National Register of Historic Places in 1978.

According to the United States Census Bureau, the city has a total area of 0.26 square miles (0.67 km2), all land.

38.5% of all households were made up of individuals, and 20.5% had someone living alone who was 65 years of age or older.

The racial makeup of the town was 98.43% White, 0.52% African American, and 1.05% from two or more races.

About 17.6% of families and 21.6% of the population were below the poverty line, including 26.1% of those under the age of eighteen and 32.1% of those 65 or over.