Grainola is a town in northwest Osage County, Oklahoma, United States.

[5] Grainola was originally named Salt Creek for a nearby tributary of the Arkansas River.

The Salt Creek post office opened in November 1906, and the townsite was officially organized in 1909.

The town supported nearby farmers and cattle ranchers, but has experienced a prolonged decline since 1920, when it had an estimated population of 500.

[5] According to the United States Census Bureau, the town has a total area of 0.2 square miles (0.52 km2), all land.