Wynona is an incorporated town in central Osage County, Oklahoma, United States.

[5] An Osage-Cherokee rancher, Antoine Rogers, settled in the area that would become the town of Wynona in 1871, after the Osage tribe had been removed from Kansas to Indian Territory by the U. S. Government.

In 1903, the Missouri, Kansas and Texas Railway (also known as the MK&T or Katy railroad) built a line across Rogers's land.

A store was built adjacent to the track, and that event is considered the establishment of Wynona, which soon became a cattle shipping point.

The first local newspaper, a weekly named the Wynona Enterprise, appeared in August 1909.

However, the town failed to put in electric service and paved streets, causing some businessmen to move elsewhere.

The end of the boom in Osage County oil production and the onset of the Great Depression caused the population to decline sharply to 1,171 in 1930 and to 652 in 1960.

[6] According to the United States Census Bureau, the town has a total area of 0.5 square miles (1.3 km2), all land.