Grand Bourg is named after the Grand Bourg villa in the Paris suburb where the leader of the Argentine War of Independence, General José de San Martín lived during part of his exile (today, a neighbourhood of Évry-Courcouronnes).

The location belonged to the 19th century estancias of Juan Andrés de Cabo and Pastor Parra.

Grosso real estate company along the Belgrano North Railway Line.

Known initially as Primero de Mayo, the station and town were renamed Grand Bourg in 1959.

The "Cemetery of Grand Bourg" was the site of one of the largest mass graves found in the aftermath of Argentina's Dirty War of the late 1970s; over three hundred cadavers thus buried were located at the cemetery in 1984.