[2] In 2001, the $380 million, 715-room, 41-floor Nile Tower wing, with a revolving restaurant and a shopping mall, was added,[2] and the hotel was relaunched in August 2001[3] as Le Royal Méridien Cairo & Nile Tower.

[4] The hotel's owners, the Saudi Egyptian Touristic Development Company (SETDC),[5] severed Le Méridien's management contract on 8 August 2002,[6] closed the 1974 wing, and operated the newer wing of the hotel independently as the Royal Nile Tower for a year, until Hyatt International assumed management of the property on 1 August 2003,[7] and the tower wing was renamed Grand Hyatt Cairo.

All foreign national Hyatt management and staff were evacuated in February 2011, as a result of the Egyptian revolution of 2011.

Following this course of action, the hotel's remaining Egyptian staff began to strike, which led Hyatt to sever all ties to the property on March 20, 2011.

[5] It was announced in 2017 that the hotel would be renamed the "Hilton Cairo Grand Nile" in 2018,[10] the name change took place in 2024.