Grande Fratello VIP 6 (also known by the acronym GFVIP6) is the sixth celebrity season of the Italian reality television franchise Grande Fratello.

Alfonso Signorini returned as the host of the main show, with season 4 housemate Adriana Volpe and businesswoman Sonia Bruganelli as opinionists.

In the fourth and fifth live shows sisters, Adriana Maria e Rosella Rota took the role of the "Popular" opinionists, and in the thirty-first and thirty-second live shows season 1 housemate Laura Freddi replaced Sonia Bruganelli who was temporarily away to celebrate New Year's Day.

[1] On November 12, 2021, Signorini announced that the season would last until March 14, 2022, making it at the time the longest Italian celebrity season and tying Grande Fratello 11 making it the longest celebrity season at the time, being later surpassed by Grande Fratello VIP 7.

The age of the housemates refers to the time of entry into the house.