In 1969, she represented Italy in the Eurovision Song Contest in Madrid with "Due grosse lacrime bianche", finishing 13th.

She represented Italy in the V Festival Internacional da Canção in Rio with "Tu non-sei più innamorato di me" in 1970.

A concert at the Paris Olympia and a tour (United States, Canada, South America and the Soviet Union) followed.

However, as the highest-polling among the candidates failing to be elected, Zanicchi took up her seat in Strasburg in May 2008, representing Forza Italia, when EuroMP Mario Mantovani left to become a PdL senator.

The idea of the group came during a conversation between the Italian comedians Valerio Lundini, who is one of the singers and the keyboard player of the band, and Greg, who suggested the name.