The school serves several areas, including Valley Glen, much of Sherman Oaks, and sections of both Van Nuys and North Hollywood.

There is a school tradition that, on or about April 1, a satirical issue is distributed called the "Oddity", which contains comical and irreverent articles.

Past "articles" have been about finals being canceled, the school being closed, rats infesting the cafeteria, clothing-optional P.E.

Connected to Grant High School is a communications/technology magnet which emphasizes smaller class sizes and communications technology electives including film/video production, broadcast journalism, computer technology, graphic communications, and performing arts.

[5] Grant's original purpose was to serve as a high school for the families of World War II veterans who were moving into the San Fernando Valley.

An LAUSD official stated a belief that the tension may have originated from earthquake relief drives held in the 1980s which were meant to benefit Armenia and Mexico.

[12] In 2006, Grant was relieved of many 9th and 10th graders by the opening of East Valley High School, which planned to phase in grades 11 and 12 in the following two years.

[8] Grant was featured in Newsweek magazine's April 17, 2008 cover story about 25 years of divorce in America; Grant was chosen as a prototypical suburban high school and the article featured members of the class of 1982 and their marital stories.

Grant students are also credited with helping to paint one of the largest murals in the world—the Great Wall of Los Angeles—in the Tujunga Wash that lies on the border of the campus.

In addition, Humanitas students have the ability to go on field trips and participate in school activities that are only accessible to them.

The Armenian students, as of 2015, originated in a wave of immigration from Armenia and the former Soviet Union that began in the early 1990s.

As of 2000 the common belief at the school was that Latinos wore baggy clothes while Armenians dressed more conservatively.

Students that have completed his program have earned numerous awards such as certificates, CINE Golden Eagles, trophies and other means of recognition.

LAUSD has conducted a project proposal that would modernize the school and create space for more students as a result of Los Angeles' rapid growing suburbia.

This is due to a number of reasons; the most commonly-cited of which is the fact that it is the only public high school within and across the entirety of the LAUSD system that has no readily-visible Palm Trees growing on the property--thus hiding its precise geographics, and giving the location a generic, "Anytown, USA" type of feel when and where production teams deemed it necessary, or when shooting for other, outside locations.

Secondary to this rationale is the long strip of road (known as "Lancer Lane") which runs between the eastern boundary of the school and a scenic greenbelt, walking path, and the Tujunga Wash, along with the availability of ample parking—combined with the ease of moving equipment around.