Grape Creek is a census-designated place (CDP) in Tom Green County, Texas, United States.

According to the United States Census Bureau in 2000, the CDP has a total area of 17.2 square miles (44.6 km2), all land.

[3][4] Grape Creek CDP is on Grape Creek just north of U.S. Highway 87 and the Gulf, Colorado and Santa Fe Railway in north central Tom Green County.

The area was populated as early as 1858, when the Butterfield Overland Mail established a Grape Creek station on the east bank of the east fork of Grape Creek near the present-day community.

State highway maps in 1936 showed the school, a church, a nearby cemetery, and scattered dwellings in the community.

As of the 2020 United States census, there were 3,594 people, 1,163 households, and 793 families residing in the CDP.