Grayville is a city in Edwards and White counties in the U.S. state of Illinois.

Grayville is the birthplace of naval hero James Meredith Helm.

While it is no longer on any major rail line, it was home to a large rail bridge across the Wabash into Indiana, but sections of that bridge collapsed in January 2005 due to a major flood[8] of the Wabash River.

[9][10] The largest bridge to Indiana south of Lawrenceville, and the only Interstate link between Illinois and Indiana south of Terre Haute, the I-64 river crossing runs parallel to the collapsed rail bridge, about 1000 feet upstream.

33.97% of all households were made up of individuals, and 20.00% had someone living alone who was 65 years of age or older.

Grayville had been at the northern end of a four-mile-long oxbow bend of the main channel of the Wabash River.

Bonpas Creek trickles through a portion of the former river channel, creating continued access to water for canoes, rafts, and extremely shallow-draft small boats.