Samsville is an unincorporated community in northern Edwards County, Illinois, United States.

Lot had been a resident of Kentucky and Tennessee before coming to the state of Illinois with his family.

By thrift, energy, and endurance, Lot Sams had accumulated a considerable amount of property, and the little hamlet of six or seven families (at the time) in Samsville, in Shelby precinct, has the honor of bearing his name.

In June 2006, strong straight-line winds destroyed the Ebenezer United Methodist Church that was located by the Cemetery.

He also entered into business with Glen Taylor operating the Southern Illinois Tractor & Machine Salvage Company.