Although camping and fishing are allowed with proper permit, no roads or buildings are constructed and there is also no logging or mining, in compliance with the 1964 Wilderness Act.

Great Bear is the origination point of the wild and scenic designated Middle Fork of the Flathead River, which flows for 50 miles (80 km) through the wilderness and is rarely visited.

Other mammals found in the wilderness include lynx, wolverine, mule deer, elk, moose, mountain goat, and bighorn sheep.

Visitors are urged when entering this remote landscape to be well versed in outdoor survival skills, have knowledge of the use of map and compass and to make sure someone knows where you're going and when you'll be back.

For the most part, winter snows have completely melted by mid May, although higher terrain may continue to have small snowfields year round.