Great Denham is a village and civil parish located in Bedfordshire, England, on the western outskirts of Bedford.

It has evidence of Neolithic settlement as well as Roman and Saxon presence in the form of coins, pottery and other implements.

In 886 the Saxons and Vikings fixed a formal boundary between them, along the rivers Thames, Lea, and Great Ouse.

St James Church, just over the border of Great Denham in the neighbouring village of Biddenham, was first constructed in the Norman period.

There is a GP surgery with ProHealth Clinic located inside it on Kingswood Way, and a Community Hall on Saxon Way.