The company became a metal producer and listed on the Toronto Stock Exchange in 2006 after a restructuring in which Robert Archer took over as Chief Executive Officer and acquired and returned several dormant silver-gold mines in Mexico back into production.

In 2015 the company merged with TSXV-listed Cangold which was attempting to develop its own gold-silver mine in Mexico.

It underwent several name changes, mergers and acquisitions and pursued several business interests throughout the 1980s and 1990s, including oil and gas development in Oklahoma,[1] agriculture as Controlled Environmental Farming International Ltd, baby bassinets as New Age Ventures[2][3] and oil again, this time in California and Thailand, as Great Panther Inc.[4] The company re-organized again in 2003-04 to become Great Panther Resources Limited, with a new CEO, Robert Archer and Francisco Ramos to pursue the development of various mineral rights in Mexico.

[8] In 2015, Great Panther Silver purchased TSXV-listed Cangold for its the Guadalupe de los Reyes gold-silver project in Sinaloa, Mexico, in an all-share deal worth $1.7 million.

[16] In late-2021, the Tucano Mine was fined US$9 million by the Brazilian Environmental Agency for an alleged cyanide pollution incident.