Great Portland Street station is listed as a building of National Significance and is in Travelcard Zone 1.

Its construction is a steel framed cream terracotta clad exterior, with the perimeter providing shops and originally a car showroom with office space over the station.

[8] The station lies at the northern end of Great Portland Street – a main road which marks the border between Marylebone and Fitzrovia.

[9][10] The local neighbourhood plan identified the gyratory around Great Portland Street Underground Station as one where public realm improvements and traffic calming should be made.

[11] The station is served by the Metropolitan, Hammersmith & City and Circle lines, between Euston Square in the east and Baker Street to the west.