It is on the Circle, Hammersmith & City and Metropolitan lines between Baker Street and Euston Square stations in fare zone 1.

Its construction is a steel framed cream terracotta clad exterior, with the perimeter providing shops and originally a car showroom, with office space over the station.

[7][8] The station lies at the northern end of Great Portland Street – a main road which marks the border between Marylebone and Fitzrovia.

[9][10] The local neighbourhood plan from 2017 identified the gyratory around Great Portland Street Underground Station as one where public realm improvements and traffic calming should be made.

[11] The station is served by the Metropolitan, Hammersmith & City and Circle lines, between Euston Square to the east and Baker Street to the west.