The new release includes songs from their eponymous debut album through 1997's Medazzaland (excluding 1995's Thank You).

However, several songs on the disc are presented in their edited forms in order to fit on a single CD.

By 2008, the collection had sold 1.3 million copies in the United States, and was certified Platinum by the RIAA.

In November 2003, the video album was released in DVD format, titled Duran Duran: Greatest – The DVD, with hidden extra materials, including alternative versions of some of the videos and interviews of the band; however, this version is much criticised for its extensive use of Easter egg features, which make it difficult to find and play some materials.

In 2005, the disc was re-issued in a "Sight & Sound" package, containing both the CD and the DVD minus all of the latter's bonus material.