The Greens' portfolio of online work now includes their main Vlogbrothers channel, Crash Course, SciShow, their podcast Dear Hank & John, and several other projects spanning several forms of media.

The blog was originally a class project of Hank's, while he studied at the University of Montana, but eventually progressed into becoming a major environmental publication, which would grab the attention of Time.

[29] Among these are organic and thermodynamic chemistry, physics, geology, climatology, astronomy and astrophysics, evolutionary biology, psychology and several miscellaneous fields.

As a result, the channel was promoted through several platforms, including billboard ads, as well as a television commercial featured during the fifth season premiere of The Walking Dead.

[34] Prior to the channel's launch, Hank Green featured Graslie giving a tour of the University of Montana's Philip L. Wright Zoological Museum on one of his Vlogbrothers videos.

[36] Regarding this transaction, Hank stated, "We helped create The Brain Scoop with Emily and Michael Aranda of our studio because she was just so passionate and enthusiastic about science, history, and her work.

[37] The channel later added to its library of videos, launching The Big Question, and Misconceptions hosted by Craig Benzine and Elliott Morgan, respectively.

[38][39] Emerson College's Entertainment Monthly paper listed Mental Floss, as well as the aforementioned Crash Course as top five educational YouTube channels.

[40] Hank Green also serves as the executive producer for Sexplanations, a channel dedicated to open and honest conversation and information about sex-related topics hosted by clinical sexologist Lindsay Doe.

Starting in May 2023, the show went on indefinite hiatus following Hank's diagnosis of Hodgkin lymphoma; his treatment, and John's need to fill in for many of his work duties, kept the brothers from recording.

Aside from the aforementioned projects, the Greens also created a sub-project of Vlogbrothers called Truth or Fail, an interactive game show on YouTube.

[69] Originally named EcoGeek LLC, it was founded by Hank Green to support his blog on environmental and science issues and was renamed in 2016.

The business affairs of the Greens' personal projects, such as the YouTube channel Vlogbrothers, are handled by Complexly but the company does not directly produce their content.

[72][73] In November 2018, Complexly fully launched a co-production arrangement with WNYC Studios for three regular podcasts; two had been produced independently before, one was new (but adapted from an old format).

[80] During an interview, Lastufka stated "Over the last few years I worked on the big ideas or product designs less and less, as my position transformed into brokering deals with brick and mortar stores and meeting with cart developers", and added "I would get a little jealous when art assignments that once went to me by default were being hired out because I just didn't have the time.

"[80] On July 26, 2013, Hank Green made a video announcing the introduction of Subbable, a crowdfunding system to support various web series (both entertainment- and education-oriented).

[88] Subbable was originally created as a crowdfunding system to continue the production of CrashCourse at the termination of the two-year Google grant that funded the project.

Additionally, Subbable presents a $0 subscription option, offering the subscriber access to special emails, behind the scenes videos and live shows.

[87][89] Hank, who has been described as "idealistic" for the idea, explained that donations to projects on Subbable are voluntary, stating in his video, "We're asking, and this is weird, for you to pay for content because you want to, not because you're forced to.

"[85][89][90] John emphasized the point of the crowdfunding system's voluntary nature, "If you're authentic toward your community and don't focus on the ads, your audience will support you.

During the project's first year, Hank Green stated, "There were more than 400 videos posted, but several people focused on humanitarian organizations in Darfur, UNICEF, Autism Speaks, The Humane Society, Toys for Tots, World Wildlife Fund, I'm proud to say that it's a very long list.

Speaking about what subjects he would like to teach on the Crash Course channel, John stated, "I'm very interested in economics and personal finance (I sometimes post at r/personalfinance) and literature and philosophy and anthropology and the list goes on and on.

[104] In their youth, the Greens' parents encouraged the brothers to discuss big issues at the dinner table, and John often argued about philosophy and ethics.

[13] Hank has been documented to be active in the crowdfunding field,[106] and would establish Subbable, allowing online content creators to have an alternative funding source aside from video advertising.

"[107] John elaborated on his valuing of engagement and connection over raw viewing numbers stating, "I don't care how many people watch or read something I make.

[125] Though the approach was somewhat different from previous years, having the three conduct interviews continued the White House's efforts to "speak directly to the American people online".

[135][136] Arguing against those who say homosexuality is unnatural, Hank Green, who is bisexual himself, states that, "the most natural thing in the world is complexity, and gender, and sexual orientation are proven over and over again to not be firm lines."

In the review, Jacobs coined the term GreenLit, a play on John's surname, Green and the word literature, to describe "realistic stories told by a funny, self-aware teenage narrator", that include, "sharp dialogue, defective authority figures, occasional boozing, unrequited crushes and one or more heartbreaking twists".

[138] Earl is an influential Nerdfighter, having started the Esther Day celebration, which has been described by HPA founder Andrew Slack, as "the first baggage-free holiday about love and gratitude".

[153] Celebrities, including British actor Benedict Cumberbatch, and American rapper Lupe Fiasco, who has compared Crash Course to crack, have also been documented as Nerdfighters.