[4] In 2010, Doe's photograph was featured alongside a personal statement as part of The Strong Women Project, exhibited at the Maureen and Mike Mansfield Library in Missoula, Montana.

She was originally photographed "in a pressed collared shirt, slacks and matching jewelry", but felt she was misrepresenting herself; Doe returned to the shoot hours later, stripped to her underwear, and slathered herself in homemade mud to retake the photos.

After her departure from the school due to budget cuts, enrollment numbers in the human-sexuality course dropped by half,[8] and by the 2017–2018 academic year, the course was gone altogether.

[8] Driven by her children's lack of sex education,[3] in April 2013, Doe partnered with Hank Green to found the YouTube channel Sexplanations, a series about human sexuality that began that July.

[9] In November 2021, Doe announced the December retirement of Sexplanations, citing two primary reasons: first, an observation that she was finding her content repetitive, and second, that her mental health had declined from nearly a decade of persistent sexual harassment and vitriolic emails and calls to her personal cell phone.