It is a part of the Greencastle Community School Corporation.

The school district, in which this is the sole comprehensive high school, includes Greencastle, Greencastle Township, and Madison Township.

[2] Greencastle High School was first established circa 1853.

It stopped functioning as the high school in 1958, and by 2018 the structure was used as the Green Tree Condominiums.

The current high school property opened in 1958.