[2] The county was organized in 1833 and is named after American Revolutionary War General Nathanael Greene.

In the 2016 presidential election, Donald Trump carried Greene County by a margin of 60% to 33%.

[14] The last Democratic presidential nominee to win Greene County was Lyndon B. Johnson in 1964.

In 2004, state residents voted on a constitutional amendment to define marriage as the union between a man and a woman.

The proposition strongly passed every single county in Missouri, with 78.99 percent voting in favor as the minimum wage was increased to $6.50 an hour in the state.

Mel Carnahan carried the county in both of his runs for governor, as did Jay Nixon.

In 2000, Bob Holden's victory in the county provided the margin that allowed him to defeat Jim Talent statewide.

The Republican Party predominantly controls politics at the local level in Greene County.

Greene County is divided into eight legislative districts in the Missouri House of Representatives; six of which are held by Republicans and two Democratic seats.

Voters in Greene County from both political parties supported candidates who finished in second place in the state at large and nationally.

Senator Hillary Clinton (D-New York) received more votes, a total of 18,322, in Greene County than any other candidate from either party.