It was originally known as "Sandy Ford", and during the American Civil War it was renamed "Station Five" for its location along the Pensacola and Georgia Railroad.

It was officially incorporated in 1907,[1][4] and named the "Town of Greenville" because during the US civil war, the women's sewing circle in the community helped sew for Confederate soldiers and after the civil war, the postmaster and residents decided to name it after the birthplace of Mrs. U.M.

The exact coordinates for the Town of Greenville is located in western Madison County at 30°28′N 83°38′W / 30.467°N 83.633°W / 30.467; -83.633 (30.467, –83.635).

According to the United States Census Bureau, the town of Greenville has a total area of 1.3 square miles (3.4 km2), all land.

[5] The climate in this area is characterized by hot, humid summers and generally mild winters.

As of the 2020 United States census, there were 746 people, 378 households, and 218 families residing in the town.

[13] As of the 2010 United States census, there were 843 people, 369 households, and 273 families residing in the town.