Greenville is a town in Piscataquis County, Maine, United States.

[2] The town is centered on the lower end of Moosehead Lake, the largest body of fresh water in the state.

Greenville is the historic gateway to the north country and a center for outdoor recreation in the area.

[3] First called T9 R10 NWP (or Township 9, Range 10, North of the Waldo Patent), the land was granted about 1812 by the Massachusetts General Court to Thornton Academy in Saco.

In 1835, Henry Gower began clearing land beside Moosehead Lake for what would develop into Greenville village.

There he erected the first hotel, a two-story building called The Seboomook House, and the first store.

On February 6, 1836, Greenville was incorporated from Haskell Plantation, and named for its green forests.

By 1846, Greenville village included two houses, two blacksmith shops and a schoolhouse.

On August 10, 1848, the town annexed land from Wilson, the remainder of which was distributed to Shirley and Elliotsville.

[4] A small steamboat was launched in 1836 to tow logs, and in 1838 the first large lake steamer began operation.

[1] Situated beside Moosehead Lake, Greenville is drained by Wilson Stream.