The Greenville and Knoxville Railroad was a South Carolina railroad that operated in the early 20th century.
The Greenville and Knoxville was formed in 1907, to reopen the 16-mile route between Greenville, South Carolina, and River Falls, South Carolina,[1] abandoned by the Carolina, Knoxville and Western Railway a few years early.
It was renamed the Greenville and Northern Railway six years later.
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