In 1997, DePaul moved to Los Angeles, where he directed his own play, Motherlove, whose cast included Joe Reitman and Karen Tarleton.
Back Stage West reviewer Paul Birchall described the play as "scathingly funny and wickedly inventive.
DePaul wrote Saving Silverman, starring Jack Black and Jason Biggs, which was released by Sony Pictures in 2001.
He then wrote Bride Wars, starring Kate Hudson, Anne Hathaway and Candace Bergen.
[8] DePaul's plays and sketch comedy have been performed by The Collective NY, a theatre company in Manhattan.