He played professionally as a defensive back with the Calgary Stampeders for seven years where he won two Grey Cup championships (in 1992 and 1998).

He is also a two-time Vanier Cup champion after winning as a player with the Wilfrid Laurier Golden Hawks in 1991 and then as a defensive coordinator with the McMaster Marauders in 2011.

[5] He was also named a 1994 CFL All-Star at safety after recording 10 interceptions, 57 defensive tackles, two sacks, and two fumble recoveries that year.

[3] The Marauders won the program's first Vanier Cup title in 2011 with Knox guiding the defense, leading to him winning his first championship as a coach.

[11] After a review by the university's human resources department, Knox was fired on October 22, 2018, having coached only five games that year.