[2][3] Proserpine–Shute Harbour Road commences as State Route 59 at an intersection with the Bruce Highway in Hamilton Plains, just north of Proserpine.

At the end of Waterson Way, State Route 59 turns south-east on the continuation of Proserpine-Shute Harbour Road.

[1] Leaving Airlie Beach the road follows a winding, generally easterly course through Jubilee Pocket, Mandalay, Flametree and Mount Rooper before reaching Shute Harbour, where it ends at an intersection with Whitsunday Drive.

[1] Land use along the road is mainly rural, with residential and industrial developments in Cannonvale, Airlie Beach and Jubilee Pocket.

In 1892 the first school in the Cannon Valley / Cannonvale area was opened to serve the local farming community.

[2][3] It runs west and north-west from Proserpine–Shute Harbour Road in Cannon Valley to the locality of Gregory River, where it joins the Bruce Highway, a distance of 14.1 kilometres (8.8 mi).