Greifswald University Hospital is owned and operated by a non-profit Anstalt des öffentlichen Rechts in cooperation with the university and serves as one of the primary hospitals in the state of Mecklenburg-Vorpommern.

It also fills the function of a tertiary referral hospital for the health care region.

An open clinic was established in 1794 with the help of the city council, where patients were treated for free with under the condition that students were present while the patient was being treated.

[citation needed] In the 19th century, many new buildings and facilities were built.

[citation needed] An entirely new hospital complex was built from 2001 to 2010 at a central campus location, thus replacing the former buildings that were scattered across the city.