Gretchen Guess (born September 5, 1969) is an American businesswoman and politician.
Born in Anchorage, Alaska, Guess received her bachelor's degree in economics from Carleton College and her master's degree in public policy analysis from University of Rochester.
From 2001 to 2003, Guess served in the Alaska House of Representatives and was a Democrat.
In 2013, Guess resigned from the school to take a job at St. Vincent's HealthCare in Jacksonville, Florida.
Her father Gene Guess also served in the Alaska Legislature.