Grevena has had access to the A2 motorway (Egnatia Odos) since the early 2000s, which now connects Igoumenitsa with Thessaloniki and Alexandroupoli at the border with Turkey.

Under Ottoman rule, Grevena was a small administrative and military centre, the seat of a kaza belonging to the Sanjak of Serfiğe within the Vilayet of Manastir.

[6] Following the Greek–Turkish population exchange, Greek refugee families in Grevena were from East Thrace (6), Asia Minor (33) and Pontus (16) in 1926.

[6] Due to its small size, the town's Ottoman past, represented through a few public buildings and the homes of Muslims located in the urban centre, all disappeared during the 20th century.

[8] The large granite fortress residence (konak) of Veli Bey was destroyed after the population exchange.

Another earthquake with a measured intensity of 5.4 occurred on 17 July 2007 at 21:23 local time (EET) and was followed by weak aftershocks.