Grevillea zygoloba is a species of flowering plant in the family Proteaceae and is endemic to the south-west of Western Australia.

It is an erect shrub with divided leaves, the lobes linear and more or less parallel, and clusters of creamy-white flowers.

Flowering occurs from September to November and the fruit is a sticky, pimply, elliptic follicle 5–7 mm (0.20–0.28 in) long.

It occurs between Koolyanobbing and the Die Hardy Range north of Southern Cross in the Avon Wheatbelt, Coolgardie, Nullarbor and Yalgoo bioregions of south-western Western Australia.

[2][3] Grevillea zygoloba is listed as "not threatened" by the Government of Western Australia Department of Biodiversity, Conservation and Attractions.