As a senior, he had an 11–3 win–loss record with a 1.51 earned run average (ERA) and 123 strikeouts, and was named the Orange County Register Pitcher of the Year.

[1][2] In his final game, he led Santa Margarita to victory in the 2014 California Interscholastic Federation SS Division I Championship, recording 11 strikeouts and allowing only two hits.

[13] On April 30, 2019, the Angels promoted Canning to the major leagues and he made his debut that night, against the Toronto Blue Jays, recording six strikeouts over 4+1⁄3 innings pitched.

He was tied for the AL lead among pitchers with three defensive runs saved and made just one error out of 16 chances.

[18] On August 10, 2021, the Angels announced that Canning would miss the rest of the season with a low back stress fracture.

In August, he was shut down after experiencing multiple setbacks in his recovery, and did not make a professional appearance on the year.

[21] Canning made 32 appearances (31 starts) for the Angels in 2024, compiling a 6–13 record and 5.19 ERA with 130 strikeouts across 171+2⁄3 innings pitched.