He was a combined 12–5 with a 2.03 earned run average (ERA) and 137 strikeouts as a two-year letterman with the Ragin' Cajuns baseball team in 1969 and 1970.

[6] He was nearly sent to the Baltimore Orioles as part of a trade deadline blockbuster on June 15, 1976, but the Yankees did not want to give up any more left-handed pitchers beyond the three (Scott McGregor, Tippy Martinez and Rudy May) that they had already included in the deal.

[7] The following year he was to have been dealt to Toronto for Bill Singer in a transaction that was approved by the Yankees but was vetoed by Blue Jays president Peter Bavasi.

In the longest outing Guidry could remember since his Eastern League days of 1974, he helped the Yankees beat the Seattle Mariners 3–0.

[14] Guidry's 18-strikeout performance is usually cited as the launching pad of the Yankee Stadium tradition of fans standing and clapping for a strikeout with two strikes on the opposing batter.

The game is best known for Bucky Dent's seventh-inning, three-run home run that gave the Yankees a 3–2 lead.

[15] He also finished second in the American League Most Valuable Player voting to Boston Red Sox slugger Jim Rice.

[20] In addition, Guidry was named The Sporting News AL Pitcher and Major League Player of the Year.

[22] In 1984, Guidry won the Roberto Clemente Award,[24] given annually to the Major Leaguer who "'best exemplifies the game of baseball, sportsmanship, community involvement and the individual’s contribution to his team.

'"[25] On August 7, 1984, Guidry struck out three batters (Carlton Fisk, Tom Paciorek and Greg Luzinski) on nine pitches in the ninth inning of a 7–0 win over the Chicago White Sox.

Each living Yankee previously honored with a plaque in Monument Park was on hand for the ceremony: Phil Rizzuto, Yogi Berra, Whitey Ford, Reggie Jackson and Don Mattingly.

Though he was interested in returning to the Yankees for the 2008 season, he was not offered a position on new manager Joe Girardi's coaching staff.