Griffin Greene (1749–1804) served as a commissary, paymaster, and quartermaster to the Continental Army during the American Revolutionary War.

And to the close of their lives, the affectionate regard in which they held each other, was nearly proverbial.”[5] They engaged in a significant volume of correspondence during the war, much of which was preserved or recorded.

He was a prominent figure in the early days of Marietta and the Northwest Territory, serving in multiple positions of government,[8] including justice of the peace, judge, postmaster, revenue collector,[9] and port inspector.

[10] He also spent time at the settlement of Belpre, Ohio and took an active part in the erection of the Farmer's Castle fortification during the Northwest Indian War.

[11] Griffin Greene was "a man of intelligent aspect, quick apprehension, and a ready, vigorous application of his mind to any subject before him.