The Canadian National Railway elevated tracks approaching Montreal Central Station cut a wide swathe between Dalhousie and Nazareth Streets around 1930.

The Lachine Canal lost its role as a major transport artery when it was replaced by the Saint Lawrence Seaway in 1959.

[citation needed] In 2014, Griffintown became part of an ongoing movement to introduce a "Quartier de l'innovation" to lower Montreal.

[6] This area would look to foster creativity and entrepreneurship in the city, designed to promote and encourage economic development for district residents.

In order to do this, the city announced plans to establish parks and bike paths and to provide permits for the building of dozens of condominium towers in the area, ranging from 10 to 20 stories high.

In 2006, a project to move the Montreal Casino to the Peel Basin, as part of an entertainment complex in partnership with the Cirque du Soleil, caused a controversy because of the social impact of the establishment of gambling in an underprivileged district.

In July 2007, promoter Devimco announced plans to develop 12 hectares of the neighborhood into a modern complex of office towers and residential homes.

Michel Régnier made a film on the subject in 1972, which used archival photos of Griffintown, along with interviews of former residents in order to paint a picture of the landscape, community, and a people.

It starts off telling the story of Ms Mary Gallagher, a prostitute who was brutally murdered in 1879 and would return every seven years to William Street in search of her head.

[8] Alan Hustak has written a book 'The Ghost of Griffintown' which explores in great detail the murder of Mary Gallagher.