After the Byzantine Empire annexed the Kingdom of Ani, Gregory went on to serve as the governor (doux) of the province of Edessa.
He collected all Armenian manuscripts of scientific or philosophical value that were to be found, including the works of Anania Shirakatsi, and translations from Callimachus, Andronicus of Rhodes and Olympiodorus.
Foremost among his writings are the "Letters," which are 80 in number, and which provide information about the political and religious problems of the time.
His chief poetical work is a long metrical narrative of the principal events recorded in the Bible.
This work was purportedly written in three days in 1045 at the request of a Muslim scholar, who, after reading it, converted to Christianity.