Groot Agelo is a hamlet in the Dutch province of Overijssel.

It is a part of the municipality of Dinkelland, and lies about 9 km north of Oldenzaal.

It was first mentioned in 1252 as "Wicherus et Ludolfus filius suus de Agelo".

It is called Groot (Big) to distinguish from Klein Agelo (Little).

In this neighbourhood some fine examples of timber-framed cottages and barns can be found, displaying the Low German house style which is very common in the east of Twente.