GHR exists in two forms as a full length membrane-bound receptor and as a soluble GH binding protein (GHBP).

Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.

Growth hormone receptor has been shown to interact with SGTA,[15] PTPN11,[16][17] Janus kinase 2,[18][19][20] Suppressor of cytokine signaling 1[21] and CISH.

[22][23][24] GHR has also proven useful at lower taxonomic levels, e.g., in octodontoid,[25][14] arvicoline,[26] muroid,[27][28] murine,[29] and peromyscine [30] rodents, in arctoid [31] and felid[32] carnivores, and in dermopterans.

[36] They are used if the tumor of the pituitary gland causing the acromegaly cannot be controlled with surgery or radiation, and the use of somatostatin analogues is unsuccessful.