The group participated in the World War 2 campaign of Romania on the Eastern Front and in the defense of the country against the Western Allied bombing raids.

The group was disbanded in October 1944 as its pilots were transferred to Grupul 1 Vânătoare after converting to the Bf 109 from the IAR 81.

In the starting days of Operation Barbarossa, it flew mainly interception missions against Soviet bombers attacking Ploiești and Bucharest.

[2] As its presence was no longer needed in the country due to the Soviet bombers being pushed outside of the range of the Ploiești oil fields, the 6th Group was sent on the frontline when Romanian Fourth Army began the Siege of Odessa.

During the 1941 campaign, fighter pilots of the group claimed 11 Soviet aircraft shot down of which five were confirmed.

In formations of eight aircraft, they departed to Odesa, then to Melitopol, and finally reached Tusov airfield near Stalingrad on 7 September.

The group was moved to the Morozovskaya airfield and starting in November the dive bombers began flying on ground attack and reconnaissance missions.

[2] In February 1943, the group began moving to the Târgșoru airfield where it was assigned to the air defense system of the Prahova Valley.

[2][4] The air raid, though a failure for the USAAF, proved that the IAR 80B's two 13.2 mm machine guns were not powerful enough to reliably take down heavy bombers.

[2] Expecting future raids, General Gheorghe Jienescu [ro] decided to restructure the fighter defenses.

By the end of November 1943, all three squadrons of Grupul 6 were relocated to the Popești-Leordeni airfield, being also equipped with the new IAR 81C, which were armed with two 20 mm MG 151 cannons.

Though a dangerous move, as the ground fire targeted everything that was flying, the IARs downed six bombers of which three were confirmed without suffering any losses.

As they were entering Romania, the heavy fighters were detected by Würzburg and Freya radars, and the IAR 81s of Grupul 6 were notified to take off.

Notified by the Luftwaffe "Tiger" command from Otopeni, Vizanty's IARs dove on the unsuspecting "two feathered Indians" over the airfield.

[15] After the 23 August 1944 coup, the 6th Fighter Group was moved to the Turnișor airfield in Transylvania to aid the ground troops in the area.

[16] A part of pilots from the 6th Group were eventually transferred to Grupul 1 Vânătoare, where they flew on Bf 109s for the rest of the war.