Guane is a municipality and town in the Pinar del Río Province of Cuba.

Before it was renamed Pinar del Río in 1774, the area was known as the old colonial capital of Guane.

The municipality was formerly divided into the barrios of Cabo de San Antonio y La Fe, Catalina, Cortés, Hato de Guane, Isabel Rubio (Paso Real de Guane), Juan Gómez, La Grifa, Las Martinas, Los Acostas, Manuel Lazo (Cayuco), Portales, Pueblo, Punta de la Sierra, Sábalo and Tenería.

[1] It was the main city of Filipino migrants to Cuba, who were known as Chinos Manila among the local population.

During that time, the Spanish colonizers had a virtual monopoly of the tobacco trade through their company, the Tabacalera.