Guardabosone is a comune (municipality) in the Province of Vercelli in the Italian region Piedmont, located about 80 kilometres (50 mi) northeast of Turin and about 45 kilometres (28 mi) northwest of Vercelli.

Guardabosone borders the following municipalities: Ailoche, Borgosesia, Caprile, Crevacuore, Postua, Scopa, Scopello, and Serravalle Sesia.

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