The Guardian Angel Settlement Association is a non-sectarian, non-profit 501c3 in St. Louis, Missouri, dedicated to empowering the disadvantaged through an array of programs which include family services, a food pantry, senior citizen support, and developmental childcare.

Founded in 1859 by the Daughters of Charity of Saint Vincent de Paul, as an orphanage for young girls Guardian Angel Settlement Association is one of the longest-enduring charitable organizations in the St. Louis area.

In 1963, To make way for a new City park, the agency moves to the Darst-Webbe public housing project on Saint Louis’ Near South Side.

In 2009, Agency celebrated 150th anniversary of serving the poor in St. Louis, August 31, 2009 with opening of new child development center.

In 2013, Guardian Angel Settlement Association established the Sr. Annalee Faherty, D.C. Service Endowment, the agency's first permanent fund.