Guarne is a town and municipality in the Colombian department of Antioquia.

The first settlers of Guarne were Tahamíes Indians who came from the Nare River.

In 1541, Alvaro Mendoza entered the Guarne area, but finding no gold, returned to the Aburrá Valley.

In 1640, searching for gold, Captain Fernando del Toro Zapata and Diego Beltran del Castillo arrived at Guarne.

This Department of Antioquia location article is a stub.