Guastalla (Guastallese: Guastàla) is a town and comune in the province of Reggio Emilia in Emilia-Romagna, Italy.

Guastalla is located at around 30 kilometres (19 mi) from the cities of Reggio Emilia, Parma, and Mantua.

The area of Guastalla was probably settled by Etruscans as early as the 7th century BC, but the name of the city is mentioned for the first time in 864 AD.

Then with the Treaty of Aix-la-Chapelle, the city became part of the Duchy of Parma, Piacenza e Guastalla, to which it belonged until 1847, when it was inherited by the Duke of Modena.

SMEG (from Smalterie Metallurgiche Emiliane Guastalla), a major manufacturer of high-end domestic appliances, was founded by Vittorio Bertazzoni in Guastalla in 1948, where it still has its headquarters.